![]() is also a consultant to Netflix, Abbott Laboratories, and CARB-X. Mayo Clinic has a royalty-bearing know-how agreement and equity in Adaptive Phage Therapeutics. has research supported by Adaptive Phage Therapeutics. is a consultant to Curetis, PathoQuest, Selux Diagnostics, 1928 Diagnostics, PhAST, Torus Biosystems, Day Zero Diagnostics, Mammoth Biosciences, and Qvella monies are paid to Mayo Clinic. reports grants from ContraFect, TenNor Therapeutics Limited, and BioFire. A.M., S.K., K.P., S.A.C., A.G.: no conflict of interest. ![]() The authors declare a conflict of interest. marcescens genomic epidemiology and facilitating interlaboratory comparisons. The scheme and its associated nomenclature will improve standardization of typing efforts for molecular surveillance and outbreak investigation, allowing better understanding of S. ![]() ![]() Analyzing 175 isolates from 24 outbreaks using the novel scheme gave comparable results to previous typing efforts for both general groupings and allelic distances within clusters. These genes formed the novel cgMLST scheme, covering 47.8% of nucleotides in the Db11 genome. Analysis of Db11 genes within the 491 data sets identified 2,692 target genes present in ≥97% of genomes (mean, 99.1% median, 99.9%). The novel scheme was evaluated using WGS data from 24 outbreak investigations ( n = 175 isolates) distributed over three continents. marcescens Db11 ( NZ_HG326223.1) as a starting point-all Db11 genes present in ≥97% data sets used to create a cgMLST scheme. marcescens WGS data sets were extracted from public databases and-using the genomic sequence of NCBI reference strain S. marcescens cgMLST scheme is reported with the goal of enabling a standardized methodology and typing nomenclature. Here, the development and evaluation of a S. marcescens core genome multilocus sequence typing (cgMLST). Although whole-genome sequencing (WGS)-based typing is the standard method for molecular surveillance and outbreak investigation, there is no standardized analytic scheme for S. Serratia marcescens can cause a range of severe infections and contributes to nosocomial outbreaks.
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